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371806 | GTP-14564 - CAS 34823-86-4 - Calbiochem

371806
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₅H₁₀N₂O 34823-86-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1371806-5MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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          Frasco de vidrio 5 mg
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          Description
          OverviewA cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, AKT, PKC, MEK, or ERK1/2 (IC50 ≥ 10 µM). Has been used successfully to differentiate between the signalling pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
          Catalogue Number371806
          Brand Family Calbiochem®
          Synonyms1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden, 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
          References
          ReferencesMurata, K., et al. 2003. J. Biol. Chem. 278, 32892.
          Product Information
          CAS number34823-86-4
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₁₅H₁₀N₂O
          Chemical formulaC₁₅H₁₀N₂O
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetClass III receptor tyrosine kinases
          Primary Target IC<sub>50</sub> 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          371806

          Referencias bibliográficas

          Visión general referencias
          Murata, K., et al. 2003. J. Biol. Chem. 278, 32892.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden, 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
          DescriptionA cell-permeable, reversible, ATP-competitive, and tricyclic, benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 300 nM for c-fms, c-kit, wt-FLT3, and internal tandem duplication (ITD)-FLT3; 1 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, Akt, PKC, MEK, or ERK1/2 (IC50 >10 µM). Inhibits FLT-3 ligand-dependent growth of Ba/F3 cells expressing wild type FLT-3. Reported to be useful in differentiating signal transduction pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number34823-86-4
          Chemical formulaC₁₅H₁₀N₂O
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesMurata, K., et al. 2003. J. Biol. Chem. 278, 32892.