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12-347 | Histone H4 Peptide

12-347
100 µg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Key ApplicationsEntrez Gene NumberUni Prot Number
      HAT, WB NM_003538.3 P62805
      Description
      Catalogue Number12-347
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHistone H4 Peptide
      References
      Product Information
      PresentationLyophilized powder
      Applications
      ApplicationHistone H4 Peptide primarily used in Histone Acetyltransferase Assays (HAT) and Western Blotting.
      Key Applications
      • Histone Acetyltransferase Assay (HAT)
      • Western Blotting
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
      Gene Symbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
      SIZE: 103 amino acids; 11367 Da
      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
      SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Immunoblot Analysis. This peptide can be used as a standard for antibodies specific for the N-terminus of histone H4. It can also be chemically acetylated with [3H]CH3COONa using the HDAC Assay Kit (17-281). The radiolabeled peptide was used to assay HDAC activity in a HeLa nuclear extract (12-309).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Histone H4 Peptide 2487892
      Histone H4 Peptide (substrate for HAT activity) - 2459574 2459574
      Histone H4 Peptide - 16515 16515
      Histone H4 Peptide - 18894 18894
      Histone H4 Peptide - 20638 20638
      Histone H4 Peptide - 21828 21828
      Histone H4 Peptide - JBC1863377 JBC1863377
      Histone H4 Peptide -2605593 2605593

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.
      Mizzen, C A, et al.
      Cell, 87: 1261-70 (1996) 1996

      Mostrar resumen
      8980232 8980232

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      Categorías

      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Control Histones