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401477 | IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem

401477
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₃₈H₂₂₉N₃₇O₄₅S

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1401477-1MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 1 mg
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          Description
          OverviewA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
          Catalogue Number401477
          Brand Family Calbiochem®
          SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
          References
          ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₃₈H₂₂₉N₃₇O₄₅S
          Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetLPS-induced IκB degradation by IKK in RAW 264.7 cells
          Primary Target IC<sub>50</sub><50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          401477

          Referencias bibliográficas

          Visión general referencias
          Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-September-2007 RFH
          SynonymsAc-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
          DescriptionA 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₅S
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
          Purity≥95% by HPLC
          SolubilityPBS, pH 7.4 (1 mg/ml)
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.