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565771 | InSolution™ γ-Secretase Inhibitor X - Calbiochem

565771
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₃₉H₅₂N₄O₆

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1565771-250UG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 250 μg
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          US1565771-500UG
          Comprobando disponibilidad...
          Disponibilidad a confirmarDisponibilidad a confirmar
          En existencia 
          Suspendido
          Cantidades limitadas disponibles
          Debe confirmarse disponibilidad
            El resto: se avisará
              El resto: se avisará
              Se avisará
              Póngase en contacto con el Servicio de Atención al Cliente

              Frasco de vidrio 500 μg
              Recuperando precio...
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              La cantidad mínima tiene que ser múltiplo de
              Al finalizar el pedido Más información
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              Description
              OverviewA cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβtotal IC50 = 17 nM, Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
              Catalogue Number565771
              Brand Family Calbiochem®
              SynonymsL-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester
              References
              ReferencesWeidemann, A., et al. 2002. Biochemistry 41, 2825.
              Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312.
              Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138.
              Shearman, M.S., et al. 2000. Biochemistry 39, 8698.
              Product Information
              ATP CompetitiveN
              FormLiquid
              FormulationA 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
              Hill FormulaC₃₉H₅₂N₄O₆
              Chemical formulaC₃₉H₅₂N₄O₆
              ReversibleN
              Structure formula Image
              Applications
              Biological Information
              Primary Targettotal
              Primary Target IC<sub>50</sub>Aβtotal 17 nM, Aβ40 48 nM, and Aβ42 67 nM in SHSY5Y cells overexpressing spβA4CTF
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              Certificados de análisis

              CargoNúmero de lote
              565771

              Referencias bibliográficas

              Visión general referencias
              Weidemann, A., et al. 2002. Biochemistry 41, 2825.
              Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312.
              Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138.
              Shearman, M.S., et al. 2000. Biochemistry 39, 8698.
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision10-September-2008 RFH
              SynonymsL-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester
              DescriptionA cell-permeable hydroxyethylene dipeptide isostere that acts as a potent and highly specific inhibitor of γ-secretase (Aβ total IC50 = 17 nM; Aβ40 IC50 = 48 nM; and Aβ42 IC50 = 67 nM in SH-SY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Also reported to block the formation of εCTF, resulting in the accumulation of α- and βCTF. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
              FormLiquid
              FormulationA 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₃₉H₅₂N₄O₆
              Structure formula
              Purity≥90% by HPLC
              Storage -20°C
              Protect from light
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
              Toxicity Standard Handling
              ReferencesWeidemann, A., et al. 2002. Biochemistry 41, 2825.
              Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312.
              Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138.
              Shearman, M.S., et al. 2000. Biochemistry 39, 8698.