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579053 | InSolution™ TAPI-1 - Calbiochem

579053
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₂₆H₃₇N₅O₅

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1579053-500UG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
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          Frasco de vidrio 500 μg
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          Description
          Catalogue Number579053
          Brand Family Calbiochem®
          References
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
          Hill FormulaC₂₆H₃₇N₅O₅
          Chemical formulaC₂₆H₃₇N₅O₅
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula Image
          Applications
          ApplicationInSolution™ TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
          Biological Information
          Primary TargetMMPs and TACE
          Primary Target IC<sub>50</sub>8.09 µM, 3.61 µM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          579053
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          DescriptionA structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).
          FormLiquid
          FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₆H₃₇N₅O₅
          Structure formula
          Purity≥97% by HPLC
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant