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IL006 | Interleukin-6 Protein, Recombinant human

IL006
20 µg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Key ApplicationsSpeciesPurity
      CULT Human Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IFN gamma.
      Description
      Catalogue NumberIL006
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-6 Protein, Recombinant human
      OverviewInterleukin-6 (IL-6) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes and hybridoma cells. It will also affect cytotoxic T-cells in combination with other factors such as IL-2 and g-interferon. Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
      Alternate Names
      • IL-6
      References
      Product Information
      PresentationLyophilized from 10 mM Sodium Citrate, pH 7.5.
      Applications
      ApplicationThe recombinant human Interleukin-6 protein (or IL-6 protein) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes & hybridoma cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IL-6 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): B-cells, hybridoma cells.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IFN gamma.
      Specific ActivityHuman IL-6 is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent mouse 7TD1 cells is <= 0.1 ng/mL, corresponding to a specific activity of >= 1 x 10(E7) units/mg.
      Entrez Gene Number
      Gene Symbol
      • IL6
      • IL-6
      • HSF
      • BSF2
      • BSF-2
      • CDF
      • IFNB2
      • HGF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
      SIZE: 212 amino acids; 23718 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: N- and O-glycosylated.
      DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
      SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1 – 0.5 mg/mL. Gently shake the solution for about 10 minutes for better solubility. Do not vortex. The solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C or -80°C.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2352336 2352336
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2382080 2382080
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2425354 2425354
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2462764 2462764
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2136582 2136582
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2208741 2208741
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2276306 2276306
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2529902 2529902
      RECOMBINANT HUMAN INTERLEUKIN-6 - 2558371 2558371
      RECOMBINANT HUMAN INTERLEUKIN-6 -2527346 2527346
      RECOMBINANT HUMAN INTERLEUKIN-6 -2545741 2545741
      RECOMBINANT HUMAN INTERLEUKIN-6 -2548157 2548157
      RECOMBINANT HUMAN INTERLEUKIN-6 -2606346 2606346
      RECOMBINANT HUMAN INTERLEUKIN-6 -2640552 2640552
      RECOMBINANT HUMAN INTERLEUKIN-6 -2659236 2659236
      RECOMBINANT HUMAN INTERLEUKIN-6 -2659769 2659769
      RECOMBINANT HUMAN INTERLEUKIN-6 -2659770 2659770
      RECOMBINANT HUMAN INTERLEUKIN-6 -2669671 2669671
      RECOMBINANT HUMAN INTERLEUKIN-6 -2669671-1 2669671-1
      RECOMBINANT HUMAN INTERLEUKIN-6 -2736696 2736696

      Ficha técnica

      Cargo
      Interleukin-6, recombinant human - Data Sheet

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      Categorías

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors