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426100 | Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem

426100
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₅H₂₄N₂O₇S 1258004-00-0

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1426100-200UG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 200 μg
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          Description
          OverviewAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM).
          Catalogue Number426100
          Brand Family Calbiochem®
          SynonymsProteasome Inhibitor VI
          References
          ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
          Fenteany, G., et al. 1995. Science 268, 726.
          Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
          Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
          Omura, S., et al. 1991. J. Antibiot. 44, 117.
          Product Information
          CAS number1258004-00-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₂₄N₂O₇S
          Chemical formulaC₁₅H₂₄N₂O₇S
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary Target20S proteasome (MCP; multicatalytic proteinase complex)
          Primary Target IC<sub>50</sub>500 nM against 20S proteasome; 10 µM against NF-κB activation
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          426100

          Referencias bibliográficas

          Visión general referencias
          Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
          Fenteany, G., et al. 1995. Science 268, 726.
          Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
          Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
          Omura, S., et al. 1991. J. Antibiot. 44, 117.

          Folleto

          Cargo
          Proteasomes Technical Bulletin

          Citas

          Título
        • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
        • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
        • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-October-2012 JSW
          SynonymsProteasome Inhibitor VI
          DescriptionAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM)
          FormWhite solid
          CAS number1258004-00-0
          Chemical formulaC₁₅H₂₄N₂O₇S
          Structure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mg/ml) or H₂O
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
          Toxicity Standard Handling
          ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
          Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
          Fenteany, G., et al. 1995. Science 268, 726.
          Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
          Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
          Omura, S., et al. 1991. J. Antibiot. 44, 117.
          Citation
        • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
        • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
        • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.