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479975 | NDGA - CAS 500-38-9 - Calbiochem

479975
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₈H₂₂O₄ 500-38-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1479975-250MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
        El resto: se avisará
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          Se avisará
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          Frasco de vidrio 250 mg
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          Description
          OverviewA cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss/3T3 cells. A powerful hydroxy radical quencher.
          Catalogue Number479975
          Brand Family Calbiochem®
          SynonymsNordihydroguaiaretic Acid
          References
          ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
          Product Information
          CAS number500-38-9
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₈H₂₂O₄
          Chemical formulaC₁₈H₂₂O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetLOX-5
          Primary Target IC<sub>50</sub>200 nM, 30 µM, and 30 µM for 5-LOX, 12-LOX, and 15-LOX, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUX1750000
          Safety Information
          R PhraseR: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          479975

          Referencias bibliográficas

          Visión general referencias
          Domin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2008 JSW
          SynonymsNordihydroguaiaretic Acid
          DescriptionA cell-permeable, antioxidant and a selective lipoxygenase (LO) inhibitor (IC50 = 200 nM, 30 µM, and 30 µM for 5-LO, 12-LO, and 15-LO, respectively) over cyclooxygenase (IC50 = 100 µM). Also shown to inhibit platelet-derived growth factor (PDGF)-stimulated DNA synthesis in Swiss 3T3 cells.
          FormCrystalline solid
          CAS number500-38-9
          RTECSUX1750000
          Chemical formulaC₁₈H₂₂O₄
          Structure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 6693
          ReferencesDomin, J., et al. 1994. J. Biol. Chem. 269, 8260.
          Goodman, Y., et al. 1994. Brain Res. 654, 171.
          Kozubik, A., et al. 1993. Exp. Hematol. 21, 138.
          Salari, H., et al. 1984. Prostagland. Leuk. Med. 13, 53.
          Hope, W.C., et al. 1983. Biochem. Pharmacol. 32, 367.