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481408 | NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

481408
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₆H₂₀N₂ 749886-87-1

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1481408-5MG
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          Frasco de vidrio 5 mg
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          Description
          OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
          Catalogue Number481408
          Brand Family Calbiochem®
          Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
          References
          ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
          Product Information
          CAS number749886-87-1
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₆H₂₀N₂
          Chemical formulaC₁₆H₂₀N₂
          ReversibleN
          Structure formula Image
          Applications
          ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
          Biological Information
          Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
          Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          481408

          Referencias bibliográficas

          Visión general referencias
          Shin, H.M., et al. 2004. FEBS Lett. 571, 50.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
          DescriptionA cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number749886-87-1
          Chemical formulaC₁₆H₂₀N₂
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.