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476485 | PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated - Calbiochem

476485
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₅₃H₁₀₀N₂₀O₁₂

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1476485-500UG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 500 μg
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          Description
          OverviewHeat-stable protein kinase inhibitor (PKI) peptide sequence (14 - 22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki = 36 nM) of cAMP-dependent protein kinase.
          Catalogue Number476485
          Brand Family Calbiochem®
          SynonymsPKI 14-22 Amide, Cell-Permeable, Myr-GRTGRRNAI-NH₂, Myristoylated Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Protein Kinase A Inhibitor 14-22 Amide, PKA Inhibitor XIII
          References
          ReferencesPaman, K., et al. 1998. J. Lipid Res. 39, 1091.
          Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289.
          Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648.
          Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461.
          Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263.
          Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
          Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304.
          Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₅₃H₁₀₀N₂₀O₁₂
          Chemical formulaC₅₃H₁₀₀N₂₀O₁₂
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetcAMP-dependent protein kinase
          Primary Target K<sub>i</sub>36 nMf or cAMP-dependent protein kinase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceMyr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          476485

          Referencias bibliográficas

          Visión general referencias
          Paman, K., et al. 1998. J. Lipid Res. 39, 1091.
          Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289.
          Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648.
          Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461.
          Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263.
          Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
          Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304.
          Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsPKI 14-22 Amide, Cell-Permeable, Myr-GRTGRRNAI-NH₂, Myristoylated Protein Kinase A Inhibitor Amide 14-22, Cell-Permeable, Protein Kinase A Inhibitor 14-22 Amide, PKA Inhibitor XIII
          DescriptionHeat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki = 36 nM) of cAMP-dependent protein kinase (PKA).
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₅₃H₁₀₀N₂₀O₁₂
          Peptide SequenceMyr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPaman, K., et al. 1998. J. Lipid Res. 39, 1091.
          Rimon, G., and Rubin M. 1998. Biochim. Biophys. Acta 1380, 289.
          Harris, T.E., et al. 1997. Biochem. Biophys. Res. Commun. 232, 648.
          Muniz, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14461.
          Zoukhri, D., et al. 1997. Am. J. Physiol. 272, C263.
          Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
          Ward, N.E. and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          Walsh, D.A. and Glass, D.B. 1991. Methods Enzymol. 201, 304.
          Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.