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554325 | Resveratrol - CAS 501-36-0 - Calbiochem

554325
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₄H₁₂O₃ 501-36-0

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1554325-25MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 25 mg
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          Ahorró ()
           
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          Description
          OverviewA phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
          Catalogue Number554325
          Brand Family Calbiochem®
          Synonymstrans-3,4ʹ,5-Trihydroxystilbene
          References
          ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
          Lin, H.Y., et al. 2002. J. Urol. 168, 748.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
          Jang, M., et al. 1997. Science 275, 218.
          Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
          Product Information
          CAS number501-36-0
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₄H₁₂O₃
          Chemical formulaC₁₄H₁₂O₃
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1
          Primary Target IC<sub>50</sub>ED50 = 15 µM against COX-1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          554325

          Referencias bibliográficas

          Visión general referencias
          Howitz, K.T., et al. 2003. Nature 425, 191.
          Lin, H.Y., et al. 2002. J. Urol. 168, 748.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
          Jang, M., et al. 1997. Science 275, 218.
          Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-January-2014 JSW
          Synonymstrans-3,4ʹ,5-Trihydroxystilbene
          DescriptionA phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number501-36-0
          Chemical formulaC₁₄H₁₂O₃
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 8158
          ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
          Lin, H.Y., et al. 2002. J. Urol. 168, 748.
          Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
          Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
          Jang, M., et al. 1997. Science 275, 218.
          Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.