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559405 | SB 225002 - CAS 182498-32-4 - Calbiochem

559405
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₁₃H₁₀BrN₃O₄ 182498-32-4

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1559405-1MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
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          Frasco de vidrio 1 mg
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          Description
          OverviewA potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
          Catalogue Number559405
          Brand Family Calbiochem®
          SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
          References
          ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
          White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
          Product Information
          CAS number182498-32-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₃H₁₀BrN₃O₄
          Chemical formulaC₁₃H₁₀BrN₃O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCXCR2
          Primary Target IC<sub>50</sub>22 nM for the inhibition of 125I-IL-8 binding to CXCR2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          559405

          Referencias bibliográficas

          Visión general referencias
          Bakshi, P., et al. 2009. ACS Chem. Biol. in press.
          White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-April-2011 RFH
          SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
          DescriptionA potent and selective antagonist of G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number182498-32-4
          Chemical formulaC₁₃H₁₀BrN₃O₄
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
          White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.