A part of Merck

567805 | Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem

567805
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Al finalizar el pedido Más información
Ahorró ()
 
Solicitar precio
Disponibilidad a confirmarDisponibilidad a confirmar
En existencia 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Ver precios y disponibilidad
      Click To Print This Page

      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₂₂H₁₉N₃O₃ 179248-59-0

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1567805-1MG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 1 mg
          Recuperando precio...
          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
          Al finalizar el pedido Más información
          Ahorró ()
           
          Solicitar precio
          Description
          OverviewA 4′-phenoxy substituted 4-anilinoquinazoline compound that acts as a potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 µM and 30 µM, respectively).
          Catalogue Number567805
          Brand Family Calbiochem®
          Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
          References
          ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
          Product Information
          CAS number179248-59-0
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₂₂H₁₉N₃O₃
          Chemical formulaC₂₂H₁₉N₃O₃
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetSrc
          Primary Target IC<sub>50</sub>44 nM and 88 nM for Src and Lck, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          567805

          Referencias bibliográficas

          Visión general referencias
          Tian, G., et al. 2001. Biochemistry 40, 7084.

          Citas

          Título
        • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
          DescriptionA potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 µM, respectively).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number179248-59-0
          Chemical formulaC₂₂H₁₉N₃O₃
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
          Citation
        • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.