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01-209 | TGFβ1

01-209
1 µg  
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      Replacement Information

      Tabla espec. clave

      Key ApplicationsSpeciesSource
      CULT Human Recombinant human TGF-Beta 1 expressed in insect cells.
      Description
      Catalogue Number01-209
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionTGFβ1
      References
      Product Information
      PresentationLypholized from sodium citrate, pH 3.5
      Applications
      Key Applications
      • Cell Culture
      Application NotesATP endpoint assay for cell number
      Biological Information
      SourceRecombinant human TGF-Beta 1 expressed in insect cells.
      Entrez Gene Number
      Entrez Gene SummaryTGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM]
      Gene Symbol
      • TGFB1
      • TGFB
      • DPD1
      • CED
      • TGF-beta-1
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01137 # Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
      SIZE: 390 amino acids; 44341 Da
      SUBUNIT: The inactive form consists of a TGFB1 homodimer non- covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Highly expressed in bone.
      PTM: Glycosylated. & The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
      DISEASE: SwissProt: P01137 # Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
      SIMILARITY: SwissProt: P01137 ## Belongs to the TGF-beta family.
      Stem Cell Type
      • Neural Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in an ATP endpoint assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size1 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categorías

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors