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662105 | Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

662105
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₇H₁₃N₃O₇ • 3H₂O

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1662105-25MG
      Comprobando disponibilidad...
      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente

          Frasco de vidrio 25 mg
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          Description
          OverviewA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
          Catalogue Number662105
          Brand Family Calbiochem®
          Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
          References
          ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.
          Product Information
          FormDark purple solid
          Hill FormulaC₁₇H₁₃N₃O₇ • 3H₂O
          Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
          Structure formula Image
          Applications
          ApplicationUbiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
          Biological Information
          Purity≥90% by HPLC (sum of two isomers)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-24/25-36-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          662105

          Referencias bibliográficas

          Visión general referencias
          Yang, Y., et al. 2007. Cancer Res. 67, 9472.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-March-2009 RFH
          Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
          DescriptionA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
          FormDark purple solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
          Structure formula
          Purity≥90% by HPLC (sum of two isomers)
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
          Toxicity Irritant
          ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.