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14-195 | c-Jun (1-169)-GST Protein, soluble, 100 µg

14-195
100 µg  
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-195
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionc-Jun (1-169)-GST Protein, soluble, 100 µg
      OverviewN-terminal, Glutathione-Stransferase (GST) tagged, fusion protein
      References
      Product Information
      Applications
      Application100 µg of c-Jun (1-169)-GST. Soluble, N-terminal, Glutathione-Stransferase (GST) tagged, fusion protein, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourcecorresponding to truncated human c-Jun (1-169) expressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
      Gene Symbol
      • JUN
      • AP1
      • p39
      • c-Jun
      Protein Targetc-Jun
      Purification MethodGlutathione agarose affinity chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
      SIZE: 331 amino acids; 35676 Da
      SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
      SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.
      Molecular Weight41 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of GST
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20 C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificados de análisis

      CargoNúmero de lote
      c-Jun (1-169)-GST, soluble - 16142 16142
      c-Jun (1-169)-GST, soluble - 17088 17088
      c-Jun (1-169)-GST, soluble - 17223 17223
      c-Jun (1-169)-GST, soluble - 17263 17263
      c-Jun (1-169)-GST, soluble - 17659 17659
      c-Jun (1-169)-GST, soluble - 18329 18329
      c-Jun (1-169)-GST, soluble - 20797 20797
      c-Jun (1-169)-GST, soluble - 21374 21374
      c-Jun (1-169)-GST, soluble - 21915 21915
      c-Jun (1-169)-GST, soluble - 23569 23569
      c-Jun (1-169)-GST, soluble - 29464 29464
      c-Jun (1-169)-GST, soluble - DAM1650312 DAM1650312
      c-Jun (1-169)-GST, soluble - DAM1695846 DAM1695846
      c-Jun (1-169)-GST, soluble - DAM1730904 DAM1730904
      c-Jun (1-169)-GST, soluble - DAM1837455 DAM1837455

      Referencias bibliográficas

      Visión general referenciasAplicación Pub Med ID
      Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA
      Kumar, N. V. and Bernstein, L. R.
      J Biol Chem, 276:32362-72 (2001) 2001

      Kinase Assay11431474 11431474
      c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase
      Paasinen-Sohns, A., et al
      J Cell Biol, 151:801-10 (2000) 2000

      Kinase Assay11076965 11076965
      Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
      Born, T. L., et al
      J Biol Chem, 273:29445-50 (1998) 1998

      9792649 9792649
      Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
      Diener, K., et al
      Proc Natl Acad Sci U S A, 94:9687-92 (1997) 1997

      Kinase Assay9275185 9275185
      Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
      Wang, X. S., et al
      J Biol Chem, 272:23668-74 (1997) 1997

      Kinase Assay9295308 9295308
      The apoptosis-inducing granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R functions through specific regions of the heterodimeric GM-CSF receptor and requires interleukin-1beta-converting enzyme-like proteases
      Iversen, P. O., et al
      J Biol Chem, 272:9877-83 (1997) 1997

      Kinase Assay9092524 9092524
      Hypoglycemia-induced c-Jun phosphorylation is mediated by c-Jun N-terminal kinase 1 and Lyn kinase in drug-resistant human breast carcinoma MCF-7/ADR cells
      Liu, X., et al
      J Biol Chem, 272:11690-3 (1997) 1997

      Kinase Assay9115218 9115218