251010 | 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

251010
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      Overview

      重要规格表

      经验配方 CAS号

      价格及供货情况

      产品目录编号库存情况 包装 数量 / 包装 价格 数量
      251010-1GMCN
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          1 gm
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          描述
          概述 Anticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
          产品目录编号 251010
          品牌系列 Calbiochem®
          同义词 Ara-C, Cytarabine, Cytosine Arabinoside
          参考
          参考 Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
          产品信息
          CAS号 147-94-4
          具有ATP竞争性 N
          形式 White solid
          Hill配方 C₉H₁₃N₃O₅
          化学配方 C₉H₁₃N₃O₅
          Molar Mass 243.2
          可逆 N
          结构配方图像
          应用
          生物信息
          主靶 Anticancer, antiviral agent that is especially effective against leukemias
          理化信息
          细胞可渗透 N
          溶解度 H₂O
          尺寸
          材料信息
          毒性学信息
          GHS安全信息
          RTECS HA5425000
          安全信息
          R相 R: 20/21/22-36/37/38-43-61

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          May cause harm to the unborn child.
          S相 S: 22-36-45

          Do not breathe dust.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          产品使用声明
          储存和货运信息
          货运代码 Ambient Temperature Only
          毒性 Harmful & Carcinogenic / Teratogenic
          储存 +2°C to +8°C
          无需冷冻 No
          特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          包装信息
          运输信息
          补充信息
          规格

          Documentation

          MSDS

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          分析证书

          标题批号
          251010

          参考

          参考信息概述
          Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
          数据表

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          版本 30-April-2008 RFH
          同义词 Ara-C, Cytarabine, Cytosine Arabinoside
          描述 Cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3'-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons.
          形式 White solid
          CAS号 147-94-4
          RTECS HA5425000
          摩尔质量 243.2
          化学配方 C₉H₁₃N₃O₅
          结构配方
          溶解度 H₂O (1 mM)
          储存 +2°C to +8°C
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
          毒性 Harmful & Carcinogenic / Teratogenic
          默克美国指数 14, 2784
          参考 Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
          Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
          Grant, S., et al. 1994. Oncol. Res. 6, 87.
          Greenberg, A.L., et al. 1994. Cancer 74, 1261.
          Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
          Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
          Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
          Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
          Este, E., et al. 1992. Blood 79, 2246.
          Owens, J.K., et al. 1992. Cancer Res. 52, 2389.