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149101 | 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

149101
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₄H₇NO₂ 22059-21-8

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      US1149101-250MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
      En existencia 
      Suspendido
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      Debe confirmarse disponibilidad
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          Frasco de vidrio 250 mg
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          Description
          OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
          Catalogue Number149101
          Brand Family Calbiochem®
          SynonymsACPC
          References
          ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
          Product Information
          CAS number22059-21-8
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₄H₇NO₂
          Chemical formulaC₄H₇NO₂
          ReversibleN
          Structure formula Image
          Applications
          Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
          Biological Information
          Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
          Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
          Purity≥ 98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGZ1110000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          149101

          Referencias bibliográficas

          Visión general referencias
          Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

          Folleto

          Cargo
          Excitotoxic Glutamate Analogs Technical Bulletin
          Pathways and Biomarkers of Glutamatergic Synapse Flyer
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          SynonymsACPC
          DescriptionA potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
          FormCrystalline solid
          CAS number22059-21-8
          RTECSGZ1110000
          Chemical formulaC₄H₇NO₂
          Structure formula
          Purity≥ 98% by TLC
          SolubilityH₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
          Zapata, A., et al. 1996. NeuroReport 7, 397.
          Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
          Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
          Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
          Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
          Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.