05-23-0753 Adrenocorticotropic Hormone 1-24, Human

05-23-0753
  
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      Přehled

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      We apologize for the inconvenience, but we do not currently have an alternative product.






      Synthetic, human adrenocorticotropic hormone (amino acids 1-24). N-Terminal synthetic fragment of pituitary hormone that stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. Directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation (ED50 = 50 nM).
      Catalogue Number05-23-0753
      Brand Family Calbiochem®
      SynonymsACTH 1-24, H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
      References
      ReferencesDarmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
      Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
      Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.
      Product Information
      CAS number16960-16-0
      FormLyophilized
      FormulationSold on the basis of peptide content.
      Hill FormulaC₁₃₆H₂₁₀N₄₀O₃₁S
      Chemical formulaC₁₃₆H₂₁₀N₄₀O₃₁S
      Hygroscopic Hygroscopic
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGM7915000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      05-23-0753

      References

      Přehled odkazů
      Darmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
      Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
      Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.

      Citations

      Název
    • Tuba Ozbay, et al. (2006) Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology 14, 1427-1437.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-September-2008 RFH
      SynonymsACTH 1-24, H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
      DescriptionSynthetic, human adrenocorticotropic hormone (amino acids 1-24). N-terminal synthetic fragment of the pituitary hormone, adrenocorticotropic hormone. Adrenocorticotropin from human pituitary glands consists of 39 amino acids. The first 24 amino acids are responsible for the biological activity of the hormone and are identical in all species. The remaining fragment has species-dependent differences in its amino acid sequence and is essential for the immunological specificity of ACTH, but is not necessary for activity. Directly activates G-proteins.
      FormLyophilized
      FormulationSold on the basis of peptide content.
      CAS number16960-16-0
      RTECSGM7915000
      Chemical formulaC₁₃₆H₂₁₀N₄₀O₃₁S
      Peptide SequenceH-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
      Purity≥98% by HPLC
      Solubility5% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 134
      ReferencesDarmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
      Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
      Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.
      Citation
    • Tuba Ozbay, et al. (2006) Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology 14, 1427-1437.