MAB5432 | Anti-CREB Antibody

MAB5432
100 µg  
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      Replacement Information

      Speciální nabídky

      Tabulka spec. kláve

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R ELISA, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB5432
      Replaces04-218
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CREB Antibody
      Alternate Names
      • cAMP-response Element Binding Protein
      Background InformationCREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.
      References
      Product Information
      FormatPurified
      Control
      • Jurkat nuclear extract, A-431 whole cell lysate
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
      Applications
      ApplicationAnti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-5 μg/mL. Recognizes the ~43kDa protein.

      ELISA: 0.1-1.0 μg/mL

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant CREB-A protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with CREB.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
      Gene Symbol
      • CREB1
      • MGC9284
      • CREB
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.
      SIZE: 341 amino acids; 36688 Da
      SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CREB -2567009 2567009
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY 2911972
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY 3136009
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY 2830976
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY 3030594
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - 2033650 2033650
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - 2398894 2398894
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - 2060964 2060964
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - 2167162 2167162
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - 2224408 2224408

      References

      Reference overviewPub Med ID
      Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
      Orr, AG; Hsiao, EC; Wang, MM; Ho, K; Kim, DH; Wang, X; Guo, W; Kang, J; Yu, GQ; Adame, A; Devidze, N; Dubal, DB; Masliah, E; Conklin, BR; Mucke, L
      Nature neuroscience  18  423-34  2015

      Zobrazit abstrakt
      25622143 25622143
      Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.
      Lin-Moshier, Y; Sebastian, PJ; Higgins, L; Sampson, ND; Hewitt, JE; Marchant, JS
      The Journal of biological chemistry  288  355-67  2013

      Zobrazit abstrakt
      23148228 23148228
      Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease.
      Yiu, AP; Rashid, AJ; Josselyn, SA
      Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  36  2169-86  2011

      Zobrazit abstrakt
      21734652 21734652
      Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts.
      Maj M, Sriskandarajah N, Hung V, Browne I, Shah B, Weadge A, Jamieson NL, Tropak M, Cameron JM, Addis JB, Robinson BH
      Mitochondrion  2010

      Zobrazit abstrakt
      21050896 21050896
      Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin.
      Yu Fukuda,Thomas L Berry,Matthew Nelson,Christopher L Hunter,Koki Fukuhara,Hideki Imai,Shinji Ito,Ann-Charlotte Granholm-Bentley,Allen P Kaplan,Tatsuro Mutoh
      Molecular and cellular neurosciences  45  2010

      Zobrazit abstrakt
      20600926 20600926

      Data Sheet

      Title
      MOUSE ANTI-CREB MONOCLONAL ANTIBODY - Data Sheet

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      Kategorie

      Life Science Research > Antibodies and Assays > Primary Antibodies