AB4340 Anti-Zscan4 Antibody

AB4340
100 µg  
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      Replacement Information

      Speciální nabídky

      Tabulka spec. kláve

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, IF, IP Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB4340
      DescriptionAnti-Zscan4 Antibody
      Alternate Names
      • Zinc finger and SCAN domain containing protein 4C
      Background InformationZinc finger and SCAN domain containing protein 4, also called Zscan4, is an embryonic stem (ES) cell-specific transcription factor required to regulate pluripotency. Zscan4 binds and regulates telomere elongation in order to maintain genomic stability and acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) in undifferentiated ES cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Embryonic Stem Cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Zscan4 Antibody is a highly specific rabbit polyclonal antibody, that targets Zinc Finger Protein & has been tested in western blotting, Immunofluorescence & IP.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      • Immunoprecipitation
      Application NotesImmunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Zscan4 in mouse iPS and R1 Embyonic Stem cells. Data courtesy of the Melanie Welham lab at The University of Bath, UK
      Immunoprecipitation Analysis: A 1:4,000 dilution from a representative lot detected Zscan4 in cytoplasmic and nuclear extracts in IP experiments conducted by the Melanie Welham lab at The University of Bath, UK. (Data not shown)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Zscan4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Zscan4c
      • Gm397
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~65 kDa observed. The calculated molecular weight of this protein is 57 kDa. An uncharacterized band may be observed at ~50 kDa in some cell lysates.ZSCAN4 bands may be observed at both ~72 kDa and ~40 kDa when preparing cell lysates with SDS buffer. Additionally, a ZSCAN4 doublet may be observed at ~72 kDa when using cytosolic or nuclear extracts.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse Embryonic Stem cell lysates.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Zscan4 in 10 µg of Embryonic Stem cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Zscan43082492
      Anti-Zscan4 - Q2144996Q2144996
      Anti-Zscan4 - 25203732520373
      Anti-Zscan4 - 32006303200630
      Anti-Zscan4 -25553092555309
      Anti-Zscan4 -25844312584431
      Anti-Zscan4 -26446042644604
      Anti-Zscan4 -26464912646491
      Anti-Zscan4 -26482022648202
      Anti-Zscan4 -26832472683247

      References

      Reference overviewPub Med ID
      Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
      Storm, MP; Kumpfmueller, B; Bone, HK; Buchholz, M; Sanchez Ripoll, Y; Chaudhuri, JB; Niwa, H; Tosh, D; Welham, MJ
      PloS one  9  e89821  2014

      Zobrazit abstrakt
      24594919 24594919
      Role of Tet proteins in enhancer activity and telomere elongation.
      Lu, F; Liu, Y; Jiang, L; Yamaguchi, S; Zhang, Y
      Genes & development  28  2103-19  2014

      Zobrazit abstrakt
      25223896 25223896