MABN254 Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3

MABN254
100 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IH(P), IF, IP, DB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN254
      DescriptionAnti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3
      Alternate Names
      • Amyloid beta A4 protein
      • ABPP
      • APPI
      • APP
      • Alzheimer's disease amyloid protein
      • cerebral vascular amyloid peptide
      • CVAP
      • PreA4
      • Protease nexin-II
      • PN-II
      Background InformationPan-amyloid-beta (1-40) is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions, including axonal transport, cell adhesion, and transcription, the Ab 1-40 peptide has been studied mostly for its potential to aggregate and form neurite plaques, which may contribute to neurotoxicity, particularly in the context of neurodegenerative disease such as Alzheimer’s. Previous studies have demonstrated that Anti-pan amyloid beta peptide (MOAB2), clone 6C3 detects specifically amyloid-beta, but not APP. Furthermore MOAB2 detects multiple amyloid-beta 40 and amyloid-beta 42 conformations including unaggregated, oligomeric and fibrillar. In a number of immunohistochemical and biochemical analyses, MOAB2 consistently detected intraneuronal amyloid-beta, but not APP, and showed greater specificity to amyloid-beta than 6E10. MOAB2 is therefore suitable for sensitive and specific detection of accumulating amyloid-beta peptides in Alzheimer’s disease models.
      References
      Product Information
      FormatPurified
      Control
      • Alzheimer's diseased human brain tissue.
      PresentationPurified mouse monoclonal IgG2aλ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 is an antibody against amyloid beta peptide (MOAB-2), pan, clone 6C3 for use in western blotting, IHC (Paraffin), Immunofluorescence, IP, Dot Blot.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      • Immunoprecipitation
      • Dot Blot
      Application NotesImmunofluorescence Analysis: A 1:1,000 dilution from a representative lot detected Amyloid Beta Peptide in human Alzeimer's diseased brain (see website for images).

      Western Blot Analysis: A representative lot was used by an independent laboratory in unaggregated forms of Aß42 and Aß40. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)

      Dot Blot Analysis: Serial Aβ40 and Aβ42 dilutions were probed with MOAB-2 or 6E10 by an independent laboratory. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)

      Immunoprecipitationt Analysis: A representative lot was used by an independent laboratory in unaggregated and fibrillar forms of Aß42 and Aß40. (Youmans, K.L., et al. (2012). Mol Neurodegener. 7;8.)
      Biological Information
      ImmunogenLinear peptide corresponding to human pan amyloid beta peptide (MOAB-2).
      Clone6C3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes amyloid-ß and not APP (amyloid precursor protein). Specifically, clone 6C3 recognizes unaggregated, oligomeric, and fibrillar forms of Aß42 and Aß40.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • APP
      • A4
      • AD1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight4 kDa calculated but could be larger since clone 6C3 recognizes unaggregated, oligomeric, and fibrillar forms of Aß42 and Aß40.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in Alzheimer's diseased human brain tissue.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Amyloid Beta Peptide in human Alzheimer's diseased brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 Analysenzertifikate

      TitelChargennummer
      Anti-amyloid beta peptide (MOAB-2), -26131282613128
      Anti-amyloid beta peptide (MOAB-2), -26601682660168
      Anti-amyloid beta peptide (MOAB-2), -27936102793610
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 24305472430547
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 22194032219403
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 22984562298456
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - 32461983246198
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 - Q2055252Q2055252
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 -25142052514205
      Anti-amyloid beta peptide (MOAB-2), pan, clone 6C3 -26405642640564

      Literatur

      ÜbersichtPub Med ID
      Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.
      Youmans, Katherine L, et al.
      Mol Neurodegener, 7: 8 (2012)  2012

      Abstract anzeigen
      22423893 22423893

      Newsletters / Publications

      Title
      Research Focus - Volume 2, 2013

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies