ABC57 | Anti-IDH2 Antibody

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Catalogue NumberABC57
      DescriptionAnti-IDH2 Antibody
      Alternate Names
      • Isocitrate dehydrogenase [NADP], mitochondrial
      • IDH
      • ICD-M
      • IDP
      • NADP(+)-specific ICDH
      • Oxalosuccinate decarboxylase
      Background InformationIsocitrate dehydrogenase [NADP], mitochondrial (IDH2) is a 452 amino acid enyzme belonging to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains mitochondrial glutathione levels. Studies suggest that IDH2 plays a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex.
      Product Information
      FormatAffinity Purified
      • Mouse heart tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect the IDH2 protein using this Anti-IDH2 validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: A previous lot of this antibody detected IDH2 in human MOLT-4 cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IDH2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008].
      Gene Symbol
      • IDH2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

      CATALYTIC ACTIVITY: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

      COFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).

      SUBUNIT STRUCTURE: Homodimer.

      SUBCELLULAR LOCATION: Mitochondrion.

      INVOLVEMENT IN DISEASE: Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2) [MIM:613657]. D2HGA2 is a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.

      SEQUENCE SIMILARITIES: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
      Molecular Weight~50 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse heart tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IDH2 in 10 µg of mouse heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies