382172 | Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem

382172
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₂₁NO₂S926908-04-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      382172-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
          Catalogue Number382172
          Brand Family Calbiochem®
          SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
          References
          ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.
          Product Information
          CAS number926908-04-5
          FormWhite solid
          Hill FormulaC₁₇H₂₁NO₂S
          Chemical formulaC₁₇H₂₁NO₂S
          Structure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          382172

          References

          Reference overview
          Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

          Technical Info

          Title
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
          DescriptionA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number926908-04-5
          Chemical formulaC₁₇H₂₁NO₂S
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.