07-742 Anti-FUBP3 Antibody

07-742
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Pm, BWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-742
      DescriptionAnti-FUBP3 Antibody
      Alternate Names
      • FUSE-binding protein 3
      • far upstream element (FUSE) binding protein 3
      • far upstream element binding protein 3
      Background InformationThe three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. The FBP, FBP2, and FBP3 genes are located on different chromosomes in mice and humans. However, their primary sequences are closely related. The FPB proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.
      References
      Product Information
      FormatAffinity Purified
      Control
      • NIH/3T3 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-FUBP3 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect FUBP3 also known as far upstream element (FUSE) binding protein 3.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot (SNAP ID) Analysis: 2 µg/ml from a representative lot detected FUBP3 on 10 µg of NIH/3T3 cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human FUBP3.
      EpitopeInternal
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes FUBP3.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Primate
      • Bovine
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Predicted to react with primate and bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FUBP3
      • FBP3
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

      SUBCELLULAR LOCATION: Nucleus Probable.

      TISSUE SPECIFICITY: Detected in a number of cell lines.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Contains 4 KH domains.

      SEQUENCE CAUTION: The sequence AAC50893.1 differs from that shown. Reason: Frameshift at position 18.

      The sequence AAH01325.1 differs from that shown. Reason: Frameshift at position 527.
      Molecular Weight~ 62 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

      Western Blot Analysis: 0.1 µg/ml of this antibody detected FUBP3 on 10 µg of NIH/3T3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies