Millipore Express® SHF Cartridge Filters

High flow sterilizing-grade PES filters for validated process steps

Overview

Specifications

Ordering Information

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Cartridges with Silicone O-rings · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP01TP30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP02TP30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP03TP30.2 µm 30 in. (75 cm) Show Pricing & Availability

Packaged 3 cartridges per box.

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Cartridges with Silicone O-rings · Code 7, 2-226 O-ring w/locking-tabs and spear Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP71TP30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP72TP30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP73TP30.2 µm 30 in. (75 cm) Show Pricing & Availability
CGEP75TP30.2 µm 5 in. (12.5 cm) Show Pricing & Availability

Packaged 3 cartridges per box.
The 10" Code 7 cartridges exist as 1 per box for validation studies (replace last digit by 1)

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Cartridges with EPDM O-rings · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP01TE30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP02TE30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP03TE30.2 µm 30 in. (75 cm) Show Pricing & Availability

Packaged 3 cartridges per box.

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Cartridges with EPDM O-rings · Code 7, 2-226 O-ring w/locking-tabs and spear Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP71TE30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP72TE30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP73TE30.2 µm 30 in. (75 cm) Show Pricing & Availability
CGEP75TE30.2 µm 5 in. (12.5 cm) Show Pricing & Availability

Packaged 3 cartridges per box.
The 10" Code 7 cartridges exist as 1 per box for validation studies (replace last digit by 1)

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Cartridges with Fluorocarbon Rubber O-rings · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP01TF30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP02TF30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP03TF30.2 µm 30 in. (75 cm) Show Pricing & Availability

Packaged 3 cartridges per box.

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Cartridges with Fluorocarbon Rubber O-rings · Code 7, 2-226 O-ring w/locking-tabs and spear Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CGEP71TF30.2 µm 10 in. (25 cm) Show Pricing & Availability
CGEP72TF30.2 µm 20 in. (50 cm) Show Pricing & Availability
CGEP73TF30.2 µm 30 in. (75 cm) Show Pricing & Availability
CGEP75TF30.2 µm 5 in. (12.5 cm) Show Pricing & Availability

Packaged 3 cartridges per box.
The 10" Code 7 cartridges exist as 1 per box for validation studies (replace last digit by 1)

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    Documentation

    Material Qualification Dossier

    Title

    Quality Management Dossier

    Title

    Operational Excellence Dossier

    Title

    Brochure

    Title
    OptiScale: a small scale screening tool for every application
    Opticap® XL and XLT Capsules Configuration Table

    Technical Info

    Title
    1X PBS (Phosphate Buffered Saline) Buffer Mixing Optimization
    Application Note: Cellvento™ CHO-100 Media Mix and Filtration Optimization
    LVP Application Performance of Millipore Express SHC and SHF 0.2 μm Membranes
    Scalable Process Filtration with Millipore Express® SHF 0.2 μm Filters
    Simplified, efficient sizing of sterilizing-grade normal flow filters for buffer solutions
    Steam-in-Place Method in the Reverse Direction for Millipore Express® PES Filters
    Sterile Filtration of Ophthalmic Solutions
    Sterile Filtration of Serum-free Mammalian Cell Culture Media
    The Vmax Nomograph Reference tool for Filter Sizing

    Posters

    Title
    Quality by Design (QbD) Principles in Aseptic Processing

    References

    Reference overview
    "Schneller und effizienter" (Faster and more efficient)
    Ulrich Hoebel, Key Account Manager for Boehringer Ingelheim & Regional Sales Manager in Central Area
    Biotechnica Today, official journal of the Hannover tradeshow Biotechnica, published by the German magazine Laborpraxis, issue October 18 2005, page 9  2005

    Filtración esterilizante rápida y económica: tecnologia de membrana Express® (Faster Sterile Filtration with New Membrane Technology)
    Josep Vilella, Bioprocess Marketing, Tech Service and internal Support Specialist in Spain
    Tecnicas de Laboratorio (Spanish magazine), issue 306, November 2005 , page 975  2005

    Increasing the Speed of Buffer Filtration; Tutorial: Millipore Express SHF Filters Utilize Composite Asymmetric Polyethersulfone Sterile Membrane
    Laurelle Sciola-Tulecke and Susan Barrett
    GEN, Volume 23, Number 14, August 2003  2003

    FAQ

    QuestionAnswer
    What is the recommended wetting procedure for Millipore Express SHF cartridges?Per Millipore's standard wetting procedure:
    Wet the dry cartridge at 1 lpm/ft2 for 5 minutes. This flow rate corresponds to 5.8 lpm (1.5 gpm) for a 5.8 ft2 cartridge.

    It is also possible to wet the filter at a lower flow rate than recommended for a longer duration (i.e.; 3L/min for 10 minutes) and pass the integrity test.
    What is the recommended wetting procedure for Millipore Express SHF 47mm discs?The wetting procedure for Millipore Express SHF discs is the same procedure for wetting Durapore 47mm discs: Dip the 47 mm disk in water or buffer prior to inserting in the holder. Make sure there are no air bubbles present between the membrane and the support material.
    What is the recommended integrity test for Millipore Express SHF filters?The recommended integrity test for Millipore Express SHF filters is either an air/water diffusion test or an enhanced bubble point test; consisting of a diffusion test followed by a bubble point test.

    Note: If a product specific integrity testing is desired, contact ACCESS services for assistance.
    How do I integrity test this filter?For diffusion testing, cartridge integrity can be measured either: 1) .visually with a downstream mass flow monitor, or 2). with an inverted graduated cylinder, or 3). using an automated integrity tester. For bubble point testing, an enhanced bubble point test (diffusion test followed by a bubble point test) using an automated integrity tester is recommended.
    What is the recommended procedure if I get a failing integrity test value?Rewet according to the SHF insert, using up to 45 psig backpressure, and retest the cartridge using either an air/water diffusion test or an enhanced bubble point test; consisting of a diffusion test followed by a bubble point test.
    What is the recommended procedure for storing Millipore Express SHF filters (pre-use)?Per the Millipore Express SHF Wetting and Integrity Testing, Package Insert (P88057): “Filter Storage Conditions: Store filters at room temperature in their original packaging and away from direct sunlight. Do not remove filter from its bag until ready to use.”
    What is the recommended procedure for returning Millipore Express SHF filters (post use)?Return filters to original packaging materials and contact Technical Services for further details.
    Is the Millipore Express PES technology platform new to Millipore?No. In 1992, Millipore was granted the first patent on the Express membrane. Millipore’s Life Science division introduced the first generation of the Express PES membrane in 1995. Since then, successive generations of the Express membrane using advanced technologies have been introduced; with the Express Plus (2002) and now the Express SHF (2003).

    Millipore Express SHF membrane is the next generation of the Millipore Express technology - enabling caustic compatible, high flow rate, process scale devices.
    What literature is available for the Millipore Express SHF?
    Millipore Express SHF LiteratureLit Ref No.
    Millipore Express SHF Data SheetDS1426EN00
    Steam-in-Place Technical BriefTB2000EN00
    Certificate of QualityP75499
    Wetting and Integrity Testing Package InsertP88057
    GEN Article: Increasing the Speed for Buffer Filtration, Aug 2003
    Validation Guide
    RP1020ENUS
    *VG1012EN00, *VG1009EN00

    * Contact Technical Service for Validation Guides.
    • For help in the U.S and Canada, call 1-800-MILLIPORE (1-800-645-5476).
    • Outside of the U.S. and Canada, call the Millipore office nearest you.
    Is Millipore Express SHF a sterilizing grade membrane?Yes. The Millipore Express SHF membrane meets ASTM requirements of quantitative retention of 107 CFU/cm2 Brevundimonas diminuta ATCC® 19146 per ASTM methodology. Millipore Express SHF has the same probability of producing a sterile effluent as Durapore. The retention standards (ASTM 838-83) and protocols (ASTM, HIMA methodology) that were used to validate Durapore membrane were used to validate Millipore Express SHF.

    User Guides

    Title
    Filters with Millipore Express® Membrane -Wetting Instructions, Integrity Testing and Drying Guidelines

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    Categories

    Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Millipore Express® > Millipore Express® SHF