481412 | NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem

481412
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula CAS #
      C₁₅H₁₃FO139141-12-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      481412-10MG
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          10 mg
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          Description
          Overview A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
          Catalogue Number 481412
          Brand Family Calbiochem®
          Synonyms (E)-2-Fluoro-4ʹ-methoxystilbene
          References
          References Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
          Product Information
          CAS number 139141-12-1
          ATP Competitive N
          Form Crystalline solid
          Hill Formula C₁₅H₁₃FO
          Chemical formula C₁₅H₁₃FO
          Molar Mass 228.3
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target NF-κB Activation
          Primary Target IC50 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          481412

          References

          Reference overview
          Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 26-July-2011 RFH
          Synonyms (E)-2-Fluoro-4ʹ-methoxystilbene
          Description A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
          Form Crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 139141-12-1
          Molar mass 228.3
          Chemical formula C₁₅H₁₃FO
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          References Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.