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149101 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

149101
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₄H₇NO₂ 22059-21-8

Products

Número de referenciaEmbalaje Cant./Env.
149101-1GM Frasco de vidrio 1 gm
149101-250MG Frasco de vidrio 250 mg
Description
OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
Catalogue Number149101
Brand Family Calbiochem®
SynonymsACPC
References
ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
Product Information
CAS number22059-21-8
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₄H₇NO₂
Chemical formulaC₄H₇NO₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
Biological Information
Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
Purity≥ 98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGZ1110000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
149101

Referencias bibliográficas

Visión general referencias
Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

Folleto

Cargo
Excitotoxic Glutamate Analogs Technical Bulletin
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-April-2008 RFH
SynonymsACPC
DescriptionA potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
FormCrystalline solid
CAS number22059-21-8
RTECSGZ1110000
Chemical formulaC₄H₇NO₂
Structure formulaStructure formula
Purity≥ 98% by TLC
SolubilityH₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.