Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

220467 2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem

220467
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₀H₁₂ClN₅O₃ 4291-63-8

Products

Número de referenciaEmbalaje Cant./Env.
220467-10MG Ampolla de plást. 10 mg
Description
OverviewA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
Catalogue Number220467
Brand Family Calbiochem®
Synonyms2CdA, Cladribine
References
ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Product Information
CAS number4291-63-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₂ClN₅O₃
Chemical formulaC₁₀H₁₂ClN₅O₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAntileukemic and immunosuppressive activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSAU7357560
Safety Information
R PhraseR: 20/21/22-36/37/38-40

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-24/25-26-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
220467

Referencias bibliográficas

Visión general referencias
Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
Synonyms2CdA, Cladribine
DescriptionA deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
FormWhite solid
CAS number4291-63-8
RTECSAU7357560
Chemical formulaC₁₀H₁₂ClN₅O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 2337
ReferencesBellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood 81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.