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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

100105
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₉H₃₇N₃O₆ 52665-69-7

Products

Número de referenciaEmbalaje Cant./Env.
100105-10MG Ampolla de plást. 10 mg
100105-1MG Ampolla de plást. 1 mg
100105-50MG Ampolla de plást. 50 mg
100105-5MG Ampolla de plást. 5 mg
Description
OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
Catalogue Number100105
Brand Family Calbiochem®
SynonymsCalcimycin
References
ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
Product Information
CAS number52665-69-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₇N₃O₆
Chemical formulaC₂₉H₃₇N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetMitochondrial ATPase
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDM4676000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
100105

Referencias bibliográficas

Visión general referencias
Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Tools and Tips for Analyzing Apoptosis
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsCalcimycin
DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
FormWhite solid
CAS number52665-69-7
RTECSDM4676000
Chemical formulaC₂₉H₃₇N₃O₆
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 1639
ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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Categorías

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores