118415 ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

118415
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      118415-1SET
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          Frasco de vidrio 1 set
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          118415-60UG
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              Ampolla de plást. 60 μg
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              Description
              OverviewAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
              Note: 1 set = 5 x 60 µg
              Catalogue Number118415
              Brand Family Calbiochem®
              SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
              References
              ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
              Product Information
              ATP CompetitiveN
              FormWhite lyophilized solid
              Hill FormulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
              Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              ApplicationADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
              Biological Information
              Primary TargetPARG
              Primary Target IC<sub>50</sub>120 nM against poly(ADP-ribose) glycohydrolase (PARG)
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              Certificados de análisis

              CargoNúmero de lote
              118415

              Referencias bibliográficas

              Visión general referencias
              Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

              Licencias necesarias e Información técnica

              Cargo
              Technical Data Sheet - 118415 Envirocheck Contact plates VRB agar (Violet Red Bile Agar)
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-October-2007 RFH
              SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
              DescriptionAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50 = 120 nM) vs. ADP-ribose (IC50 = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
              FormWhite lyophilized solid
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityH₂O (5 mg/ml)
              Storage -20°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
              Toxicity Standard Handling
              ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
              Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.