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101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₈H₁₀FNO₂S · HCl 30827-99-7

Products

Número de referenciaEmbalaje Cant./Env.
101500-100MG Frasco de vidrio 100 mg
101500-1GM Frasco de vidrio 1 gm
101500-500MG Ampolla de plást. 500 mg
101500-50MG Frasco de vidrio 50 mg
Description
OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
Catalogue Number101500
Brand Family Calbiochem®
Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
Application Data
References
ReferencesCitron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
Product Information
CAS number30827-99-7
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₈H₁₀FNO₂S · HCl
Chemical formulaC₈H₁₀FNO₂S · HCl
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetchymotrypsin
Purity>97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
101500

Referencias bibliográficas

Visión general referencias
Citron, M., et al. 1996. Neuron 17, 171.
Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
Mintz, G.R. 1993. BioPharm. 6, 34.
Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.

Folleto

Cargo
Bulk Product Guide

Citas

Título
  • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision27-September-2013 JSW
    Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
    Application Data
    DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
    FormWhite to off-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number30827-99-7
    Chemical formulaC₈H₁₀FNO₂S · HCl
    Structure formulaStructure formula
    Purity>97% by HPLC
    SolubilityH₂O (25 mg/ml)
    Storage +15°C to +30°C
    Protect from moisture
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
    Toxicity Standard Handling
    ReferencesCitron, M., et al. 1996. Neuron 17, 171.
    Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
    Mintz, G.R. 1993. BioPharm. 6, 34.
    Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
    Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
    Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
    Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
    Citation
  • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
  • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.