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123040 AICA-Riboside - CAS 2627-69-2 - Calbiochem

123040
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₉H₁₄N₄O₅ 2627-69-2

Products

Número de referenciaEmbalaje Cant./Env.
123040-50MG Ampolla de plást. 50 mg
Description
OverviewA cell-permeable nucleoside compound whose phosphorylated metabolite activates adenosine monophosphate-activated protein kinase (AMPK) and acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in perfused and isolated muscle. Offers protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and Aβ peptide.
Catalogue Number123040
Brand Family Calbiochem®
SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
References
ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
Hayashi, T., et al. 1998. Diabetes 47, 1369.
Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
Product Information
CAS number2627-69-2
ATP CompetitiveN
FormTan solid
Hill FormulaC₉H₁₄N₄O₅
Chemical formulaC₉H₁₄N₄O₅
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAdenosine monophosphate-activated protein kinase (AMPK)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AICA-Riboside - CAS 2627-69-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

AICA-Riboside - CAS 2627-69-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
123040

Referencias bibliográficas

Visión general referencias
Meli, M., et al. 2006. J. Med. Chem. in press.
Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
Hayashi, T., et al. 1998. Diabetes 47, 1369.
Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsAcadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-riboside, Z-Riboside, AMPK Signaling Activator II
DescriptionA cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid β (Aβ) peptide.
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2627-69-2
Chemical formulaC₉H₁₄N₄O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityMethanol (10 mg/ml) or H₂O. May require heating to 50°C to achieve complete solubilization in methanol.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMeli, M., et al. 2006. J. Med. Chem. in press.
Culmsee, C., et al. 2001. J. Mol. Neurosci. 17, 45.
Muoio, D.M., et al. 1999. Biochem. J. 338, 783.
Hayashi, T., et al. 1998. Diabetes 47, 1369.
Corton, J.M., et al. 1995. Eur. J. Biochem. 229, 558.