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171260 AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

171260
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₄H₂₅N₅O 866405-64-3

Products

Número de referenciaEmbalaje Cant./Env.
171260-10MG Ampolla de plást. 10 mg
171260-1MG Ampolla de plást. 1 mg
171260-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
Catalogue Number171260
Brand Family Calbiochem®
Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
References
ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Product Information
CAS number866405-64-3
ATP CompetitiveY
FormLight yellow solid
Hill FormulaC₂₄H₂₅N₅O
Chemical formulaC₂₄H₂₅N₅O
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAMPK
Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
171260

Referencias bibliográficas

Visión general referencias
Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-March-2012 JSW
Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
DescriptionA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number866405-64-3
Chemical formulaC₂₄H₂₅N₅O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (4 mg/ml), 2% HCl (10 mg/ml), 2% Acetic Acid (10 mg/ml), or Methanol (3 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.