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182200 βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem

182200
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₂H₉NO₆ 24269-96-3

Products

Número de referenciaEmbalaje Cant./Env.
182200-5MG Ampolla de plást. 5 mg
Description
OverviewA selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
Catalogue Number182200
Brand Family Calbiochem®
Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
References
ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.
Product Information
CAS number24269-96-3
ATP CompetitiveN
FormYellow to orange solid
Hill FormulaC₁₂H₉NO₆
Chemical formulaC₁₂H₉NO₆
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetβARK1 (β-Adrenergic Receptor Kinase 1)
Primary Target IC<sub>50</sub>126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
182200

Referencias bibliográficas

Visión general referencias
Iino, M., et al. 2002. J. Med. Chem. 45, 2150.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2016 JSW
Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
DescriptionA selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.
FormYellow to orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number24269-96-3
Chemical formulaC₁₂H₉NO₆
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.