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118500 ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₁H₁₇NO₃S₂ 587871-26-9

Products

Número de referenciaEmbalaje Cant./Env.
118500-10MG Frasco de vidrio 10 mg
118500-2MG Frasco de vidrio 2 mg
Description
OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
Catalogue Number118500
Brand Family Calbiochem®
Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
References
ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.
Product Information
CAS number587871-26-9
ATP CompetitiveY
FormWhite solid
Hill FormulaC₂₁H₁₇NO₃S₂
Chemical formulaC₂₁H₁₇NO₃S₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetATM Kinase
Primary Target IC<sub>50</sub>13 nM
Primary Target K<sub>i</sub>2.2 nM for ATM kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
118500

Referencias bibliográficas

Visión general referencias
Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-February-2014 JSW
Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number587871-26-9
Chemical formulaC₂₁H₁₇NO₃S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (4 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
Hickson, I., et al. 2004. Cancer Res. 64, 9152.