114825 | Adapalene - CAS 106685-40-9 - Calbiochem

114825
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical FormulaCAS #
      C₂₈H₂₈O₃ 106685-40-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      114825-25MG
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      Disponibilidad a confirmarDisponibilidad a confirmar
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      Debe confirmarse disponibilidad
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          25 mg
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          Description
          OverviewA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
          Catalogue Number114825
          Brand Family Calbiochem®
          SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
          References
          ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
          Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
          Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
          Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
          Product Information
          CAS number106685-40-9
          FormWhite solid
          Hill FormulaC₂₈H₂₈O₃
          Chemical formulaC₂₈H₂₈O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Certificados de análisis

          CargoNúmero de lote
          114825

          Referencias bibliográficas

          Visión general referencias
          Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
          Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
          Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
          Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-September-2010 RFH
          SynonymsCD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
          DescriptionA cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number106685-40-9
          Chemical formulaC₂₈H₂₈O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (12 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesIrby, C.E., et al. 2008. J. Adolesc. Health 43, 421.
          Ocker, M., et al. 2003. Int. J. Cancer 107, 453.
          Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349.
          Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96.

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          Categorías

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Vitamins, Coenzymes and Cofactors