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116815 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem

116815
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH 71774-13-5

Products

Número de referenciaEmbalaje Cant./Env.
116815-10UMOL Ampolla de plást. 10 umol
Description
OverviewA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.
Note: 10 µmol = 4.47 mg.
Catalogue Number116815
Brand Family Calbiochem®
SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
References
ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
Product Information
CAS number71774-13-5
ATP CompetitiveN
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormCrystalline solid
Hill FormulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetcAMP-receptor proteins
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
116815

Referencias bibliográficas

Visión general referencias
Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-October-2007 JSW
SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
DescriptionA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λmax = 258 nm; εmax = 15,000 M-1cm-1 (pH 7..0).
FormCrystalline solid
CAS number71774-13-5
Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (20 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.