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119136 Adenosine A1 Receptor Agonist II, CCPA - CAS 37739-05-2 - Calbiochem

119136
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Número de referenciaEmbalaje Cant./Env.
119136-10MG Frasco de vidrio 10 mg
Description
OverviewAn adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.
Catalogue Number119136
Brand Family Calbiochem®
Synonyms(2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine
References
ReferencesBurgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
Monopoli, A., et al. 1994.Arzneimittelforschung. 44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.
Product Information
CAS number37739-05-2
FormWhite solid
Hill FormulaC₁₅H₂₀ClN₅O₄
Chemical formulaC₁₅H₂₀ClN₅O₄
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetA1
Primary Target K<sub>i</sub>2.3 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A1 Receptor Agonist II, CCPA - CAS 37739-05-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
Monopoli, A., et al. 1994.Arzneimittelforschung. 44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2013 JSW
Synonyms(2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine
DescriptionAn adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number37739-05-2
Chemical formulaC₁₅H₂₀ClN₅O₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mM) or H₂O (5 mM)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBurgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
Monopoli, A., et al. 1994.Arzneimittelforschung. 44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.