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119147 Adenosine A1 Receptor Antagonist I, DPCPX - CAS 102146-07-6 - Calbiochem

119147
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Número de referenciaEmbalaje Cant./Env.
119147-25MG Frasco de vidrio 25 mg
Description
OverviewA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
Catalogue Number119147
Brand Family Calbiochem®
Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
References
ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
Blood, A. B., et al. 2003. J Physiol. 553, , 935.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
Product Information
CAS number102146-07-6
FormWhite solid
Hill FormulaC₁₆H₂₄N₄O₂
Chemical formulaC₁₆H₂₄N₄O₂
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetA1
Primary Target K<sub>i</sub>3.9 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A1 Receptor Antagonist I, DPCPX - CAS 102146-07-6 - Calbiochem Certificados de análisis

CargoNúmero de lote
119147

Referencias bibliográficas

Visión general referencias
Migita, H., et al. 2008. J Neurosci Res. 86, 2820.
Blood, A. B., et al. 2003. J Physiol. 553, , 935.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2013 JSW
Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
DescriptionA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number102146-07-6
Chemical formulaC₁₆H₂₄N₄O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (5 mM)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
Blood, A. B., et al. 2003. J Physiol. 553, , 935.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.