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119148 Adenosine A1 Receptor Antagonist II, PSB-36 - CAS 524944-72-7 - Calbiochem

119148
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₁H₃₀N₄O₃ 524944-72-7

Products

Número de referenciaEmbalaje Cant./Env.
119148-10MG Frasco de vidrio 10 mg
Description
OverviewA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
Catalogue Number119148
Brand Family Calbiochem®
Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
References
ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
Weyler, S., et al. 2006. ChemMedChem. 1, 891.
Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
Product Information
CAS number524944-72-7
FormTan powder
Hill FormulaC₂₁H₃₀N₄O₃
Chemical formulaC₂₁H₃₀N₄O₃
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A1 Receptor Antagonist II, PSB-36 - CAS 524944-72-7 - Calbiochem Certificados de análisis

CargoNúmero de lote
119148

Referencias bibliográficas

Visión general referencias
Bilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
Weyler, S., et al. 2006. ChemMedChem. 1, 891.
Tupfer, M., et al. 2008. Cell Biochem. 25, 833.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2014 JSW
Synonyms1-butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine, PSB36, PSB-36, PSB 36
DescriptionA xanthine derivative that acts as a highly potent and selective antagonist of adenosine A1 receptor (A1R; Ki = 124 pM for rat A1R and 700 pM for human A1R). Exhibits much reduced effect on A2A, A2B, and A3 receptors (Ki = 980, 187, and 2300 nM, respectively). Shown to be more potent than DPCPX (EC50 = 120 pM vs 2.9 nM). Exhibits anti-inflammatory and analgesic effects through a central mechanism. Also reported to modulate insulin release in INS-1 cells.
FormTan powder
Intert gas (Yes/No) Packaged under inert gas
CAS number524944-72-7
Chemical formulaC₂₁H₃₀N₄O₃
Purity≥98% by HPLC
SolubilityDMSO (20 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377, 65.
Weyler, S., et al. 2006. ChemMedChem. 1, 891.
Tupfer, M., et al. 2008. Cell Biochem. 25, 833.