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119152 Adenosine A₃ Receptor Antagonist, MRS 1523 - CAS 212329-37-8 - Calbiochem

119152
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₃H₂₉NO₃S 212329-37-8

Products

Número de referenciaEmbalaje Cant./Env.
119152-5MG Frasco de vidrio 5 mg
Description
OverviewA pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9 nM for human A3R, and 113 nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6 µM and 2.05 µM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA (Cat. No. 119139) on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA (Cat. No. 119140)-induced bronchoconstriction in an allergic murine model.
Catalogue Number119152
Brand Family Calbiochem®
Synonyms3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523
References
ReferencesChen, Z., 2012. FASEB J. 26, 1855.
Chanyshev, B., et al. 2012. Pharmacol Res.65, 338.
Choi, I., et al. 2011. Am J Pathol. 179, 2042.
Fan, M., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284, L1012.
Li, A. H., et al. 1998. J Med Chem. 41, 3186.
Jacobson, K. A., et al. 1999. Drug Dev Res. 45, 113.
Product Information
CAS number 212329-37-8
FormClear to light brown oil
Hill FormulaC₂₃H₂₉NO₃S
Chemical formulaC₂₃H₂₉NO₃S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetA₃ Receptor
Primary Target K<sub>i</sub>18.9 nM
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Referencias bibliográficas

Visión general referencias
Chen, Z., 2012. FASEB J. 26, 1855.
Chanyshev, B., et al. 2012. Pharmacol Res.65, 338.
Choi, I., et al. 2011. Am J Pathol. 179, 2042.
Fan, M., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284, L1012.
Li, A. H., et al. 1998. J Med Chem. 41, 3186.
Jacobson, K. A., et al. 1999. Drug Dev Res. 45, 113.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-March-2018 JSW
Synonyms3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523
DescriptionA pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9 nM for human A3R, and 113 nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6 µM and 2.05 µM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA (Cat. No. 119139) on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA (Cat. No. 119140)-induced bronchoconstriction in an allergic murine model.
FormClear to light brown oil
Intert gas (Yes/No) Packaged under inert gas
CAS number 212329-37-8
Chemical formulaC₂₃H₂₉NO₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, Z., 2012. FASEB J. 26, 1855.
Chanyshev, B., et al. 2012. Pharmacol Res.65, 338.
Choi, I., et al. 2011. Am J Pathol. 179, 2042.
Fan, M., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284, L1012.
Li, A. H., et al. 1998. J Med Chem. 41, 3186.
Jacobson, K. A., et al. 1999. Drug Dev Res. 45, 113.