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124011 Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

124011
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₃₁H₂₇IN₄S 681281-88-9

Products

Número de referenciaEmbalaje Cant./Env.
124011-1MG Frasco de vidrio 1 mg
124011-5MG Ampolla de plást. 5 mg
Description
OverviewA cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
Catalogue Number124011
Brand Family Calbiochem®
References
ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.


Product Information
CAS number681281-88-9
ATP CompetitiveN
FormYellow solid
Hill FormulaC₃₁H₂₇IN₄S
Chemical formulaC₃₁H₂₇IN₄S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Applications
ApplicationAkt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
124011

Referencias bibliográficas

Visión general referencias
Kau, T.R., et al. 2003. Cancer Cell 4, 463.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.


Folleto

Cargo
Akt
Biologics 31.1

Citas

Título
  • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.
  • Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision23-November-2009 RFH
    DescriptionA cell-permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3-K.
    FormYellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number681281-88-9
    Chemical formulaC₃₁H₂₇IN₄S
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage +2°C to +8°C
    Hygroscopic
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



    Selected Citations
    Lee, J., et al. 2009. Cell Stem Cell 5, 76.


    Citation
  • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.