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124032 Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem

124032
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₀H₃₁N₃O₂S₂ 1191951-57-1

Products

Número de referenciaEmbalaje Cant./Env.
124032-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8 µM, Ki = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1 µM, Ki = 5.5 µM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC50 = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389 levels.
Catalogue Number124032
Brand Family Calbiochem®
SynonymsPDK1 Inhibitor III, PHT-427, 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
References
ReferencesMeuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.
Product Information
CAS number1191951-57-1
FormWhite solid
Hill FormulaC₂₀H₃₁N₃O₂S₂
Chemical formulaC₂₀H₃₁N₃O₂S₂
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
124032

Referencias bibliográficas

Visión general referencias
Meuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsPDK1 Inhibitor III, PHT-427, 4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
DescriptionA cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8 µM, Ki = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1 µM, Ki = 5.5 µM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC50 = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389 levels.
FormWhite solid
CAS number1191951-57-1
Chemical formulaC₂₀H₃₁N₃O₂S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMeuillet, E.J., et al. 2010. Mol. Cancer Ther. 9, 706.
Moses, S.A., et al. 2009. Cancer Res. 69, 5073.