Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

164640
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₉H₂₆ClN₇O 220792-57-4

Products

Número de referenciaEmbalaje Cant./Env.
164640-5MG Ampolla de plást. 5 mg
Description
OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
Catalogue Number164640
Brand Family Calbiochem®
Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
References
ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
Knockaert, M., et al. 2002.Oncogene 21, 6413.
Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
Product Information
CAS number220792-57-4
ATP CompetitiveY
DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
FormPale yellow solid
Hill FormulaC₁₉H₂₆ClN₇O
Chemical formulaC₁₉H₂₆ClN₇O
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificados de análisis

CargoNúmero de lote
164640

Referencias bibliográficas

Visión general referencias
Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
Knockaert, M., et al. 2002.Oncogene 21, 6413.
Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-April-2008 RFH
Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number220792-57-4
Chemical formulaC₁₉H₂₆ClN₇O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (40 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
Knockaert, M., et al. 2002.Oncogene 21, 6413.
Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.