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172104 Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem

172104
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Número de referenciaEmbalaje Cant./Env.
172104-50MG Frasco de vidrio 50 mg
Description
OverviewTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
Catalogue Number172104
Brand Family Calbiochem®
SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
References
ReferencesSackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell 18, 382.
Product Information
CAS number1784-03-8
FormWhite solid
Hill FormulaC₁₄H₂₂N₄O₄S · HCl
Chemical formulaC₁₄H₂₂N₄O₄S · HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
172104

Referencias bibliográficas

Visión general referencias
Sackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell 18, 382.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-April-2012 JSW
SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
DescriptionTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1784-03-8
Chemical formulaC₁₄H₂₂N₄O₄S · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell 18, 382.