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182540 Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem

182540
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₁₇H₁₁N₃O₄ 331684-05-0

Products

Número de referenciaEmbalaje Cant./Env.
182540-1MG Ampolla de plást. 1 mg
Description
OverviewA potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.
Catalogue Number182540
Brand Family Calbiochem®
Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
References
ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.
Product Information
CAS number331684-05-0
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₇H₁₁N₃O₄
Chemical formulaC₁₇H₁₁N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetP450 arom.
Primary Target IC<sub>50</sub>40 nM against P450arom
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem Certificados de análisis

CargoNúmero de lote
182540

Referencias bibliográficas

Visión general referencias
Recanatini, M., et al. 2001. J. Med. Chem. 44, 672.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
DescriptionA potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC50 = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number331684-05-0
Chemical formulaC₁₇H₁₁N₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRecanatini, M., et al. 2001. J. Med. Chem. 44, 672.