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189400 Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

189400
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₂H₁₄O₉ 4431-00-9

Products

Número de referenciaEmbalaje Cant./Env.
189400-100MG Ampolla de plást. 100 mg
Description
OverviewA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
Dye content: ~85%.
Catalogue Number189400
Brand Family Calbiochem®
SynonymsATA
References
ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.
Product Information
CAS number4431-00-9
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₂H₁₄O₉
Chemical formulaC₂₂H₁₄O₉
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetDNA topoisomerase 2
Primary Target IC<sub>50</sub>75 nM against DNA topoisomerase II
Purity≥85% by Titration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGU4790000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem Certificados de análisis

CargoNúmero de lote
189400

Referencias bibliográficas

Visión general referencias
Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2019 JSW
SynonymsATA
DescriptionA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is also a potent inhibitor of DNA topoisomerase II. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA has been reported to stimulate the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase C-γ. Dye content: ~85%.
FormRed solid
CAS number4431-00-9
RTECSGU4790000
Chemical formulaC₂₂H₁₄O₉
Structure formulaStructure formula
Purity≥85% by Titration
Solubility0.1 M NaOH (35 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.