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203646 BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem

203646
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Descripción

Replacement Information

Tabla espec. clave

Empirical FormulaCAS #
C₂₄H₂₀N₄O 1206711-16-1

Products

Número de referenciaEmbalaje Cant./Env.
203646-5MG Frasco de vidrio 5 mg
Description
OverviewA cell-permeable, potent, and highly selective BMPR inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM), exhibiting no activity toward ALK5, ALK6, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Comparing to its non-BMPR-selective structural analog dorsomorphin (Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent dorsoventral development (EC100 = 0.2 µM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel formation even at concentrations as high as 50 µM.
Catalogue Number203646
Brand Family Calbiochem®
SynonymsALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
References
ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
Product Information
CAS number1206711-16-1
FormOrange solid
Hill FormulaC₂₄H₂₀N₄O
Chemical formulaC₂₄H₂₀N₄O
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem Certificados de análisis

CargoNúmero de lote
203646

Referencias bibliográficas

Visión general referencias
Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-March-2012 JSW
SynonymsALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
DescriptionA cell-permeable, potent, and highly selective BMPR (bone morphogenetic protein receptor) inhibitior (IC50 against human ALK2/BMPR-I = 107.9 nM) that exhibits no inhibitory activity against ALK5, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Effectively blocks ALK2- and ALK3-, but not ALK6-, mediated transcription activity (IC50 <500 nM, <100 nM, and >10 µM in reporter assays using C2C12BRA expressing constitutively active ALK2, ALK3, or ALK6, respectively). Comparing to its non-BMPR-selective structural analog dorsomorphin (DM; Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent DV (dorsoventral) development (EC100 = 0.2 µM DMH1 or 2.5 µM DM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel (ISV) formation even at concentrations as high as 50 µM.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1206711-16-1
Chemical formulaC₂₄H₂₀N₄O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (16.6 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.