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219672 CFTR Inhibitor III, OXO-172 - Calbiochem

219672
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₈H₁₀F₃NO₄S

Products

Número de referenciaEmbalaje Cant./Env.
219672-10MG Ampolla de plást. 10 mg
Description
OverviewA cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
Catalogue Number219672
Brand Family Calbiochem®
Synonyms3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
References
ReferencesSonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.
Product Information
FormOff-white solid
Hill FormulaC₁₈H₁₀F₃NO₄S
Chemical formulaC₁₈H₁₀F₃NO₄S
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC and NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38-43

Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
S PhraseS: 26-36/37-45-61

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CFTR Inhibitor III, OXO-172 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

CFTR Inhibitor III, OXO-172 - Calbiochem Certificados de análisis

CargoNúmero de lote
219672

Referencias bibliográficas

Visión general referencias
Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-November-2011 RFH
Synonyms3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
DescriptionA cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₀F₃NO₄S
Structure formulaStructure formula
Purity≥95% by HPLC and NMR
SolubilityDMSO (50 mg/ml) or Ethanol (1 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesSonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem. 16, 8187.